Zyrtec (cetirizine) is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Zyrtec, is the antihistamine, which is used for the condition where there is an allergic reaction within the body. Like a runny nose, skin allergies and more types of allergies. Like a runny nose, skin allergies and more types of allergies. Is Zyrtec an NSAID? SAVE CANCEL. already exists. Would you like to merge this question into it? MERGE CANCEL. already exists as an alternate of this question. Would you like to make it the primary and merge this question into it? MERGE CANCEL. exists and is an. How to use Zyrtec-D. If you are taking the over-the-counter product to self-treat, read all directions on the product package before taking this medication. Thank you for your question! No, Zyrtec-D does not contain any nonsteroidal inti-inflammatory medications. Zyrtec-D has two active ingredients, cetirizine and psuedoephedrine. Cetirizine is an. The other active ingredient in Zyrtec is Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose). Dilated blood vessels can cause nasal congestion (stuffy nose). I've been taking Zyrtec for at least 2 years straight. My bottle ran out, and I decided to wait until I go shopping to buy another. It's been 3 days, and I have had unbearable itching/hotness and hives on my scalp. A second generation antihistamine, decongestant and nsaid are recommended for certain otherwise healthy patients suffering from allergies, concomitantly with antibiotics in respiratory infections, etc. Decongestants can cause hypertension, tachycardia, etc in certain susceptible patients. Zyrtec Pollen season, nasanex, allergies I have been taking a combination of Pataday, Zyrtec, Nasonex and Advil for the last 4 years for my seasonal allergies. Find information about common, infrequent and rare side effects of Zyrtec Oral.